The doctor said to him, "Take this medicine twice a day."

  1. The doctor advised him take this medicine twice a day.
  2. The doctor advised that take the medicine twice a day.
  3. The doctor said him to take that medicine twice a day.
  4. The doctor advised him to take that medicine twice a day.
Answer

D) The doctor advised him to take that medicine twice a day.

Advice → advised + object + to + V1; this → that. Direct & Indirect Speech · Commands & exclamations

English MCQ · More English: Direct & Indirect Speech MCQs · Practise